4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline
H-1152 Dihydrochloride
CAS: 871543-07-6
Molecular Formula: C16H21N3O2S
4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline - Names and Identifiers
4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline - Physico-chemical Properties
| Molecular Formula | C16H21N3O2S |
| Molar Mass | 319.42184 |
| Melting Point | 182-184°C |
| Solubility | Methanol, Water |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| Stability | Hygroscopic |
| In vitro study | H-1152 dihydrochloride is an inhibitor of Rho-kinase, with an IC 50 of 12 nM for ROCK2. H-1152 (H-1152P) also shows less inhibitory activities against CaMKII, PKG, AuroraA, PKA, Src, PKC, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC 50 s of 0.180, 0.360, 0.745, 3.03, 3.06, 5.68, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively. H-1152 potently inhibits Rho kinase, with a K i of 1.6 nM, and slightly suppresses PKA, PKC and MLCK, with K i s of 0.63, 9.27, and 10.1 μM, respectively. H-1152 (0.1-10 µM) highly inhibits MARCKS phosphorylation, with an IC 50 value of 2.5 µM in LPA-treated cells, but shows no such obvious effects in PDBu-treated cells. H-1152 (0.5-10 μM) cuases no decreased neuronal survival. H-1152 (1, 5 or 10 μM) also exerts no alterations in the ratios of different neuronal morphologies. Furthermore, H-1152 (10 μM) increases neurite length in both BMP4 and LIF cultures. |
4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.549 ml | 12.744 ml | 25.488 ml |
| 5 mM | 0.51 ml | 2.549 ml | 5.098 ml |
| 10 mM | 0.255 ml | 1.274 ml | 2.549 ml |
| 5 mM | 0.051 ml | 0.255 ml | 0.51 ml |
Last Update：2024-01-02 23:10:35
4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline - Introduction
H1152 Dihydrochloride is a pharmaceutical compound with a variety of properties and uses. The following is a basic introduction about H1152 dihydrochloride:
Nature:
H1152 dihydrochloride (chemical name:(R)-( )-2-Cyano-3-(3-(4-pyridyl)thieno[3,2-d]pyrimidin-6-yl)prop-2-enamide dihydrochloride) it is a white to yellowish Crystal, solid at room temperature. It is a selective Rho-kinase inhibitor that inhibits the transforming growth factor beta (TGF-β) signaling pathway.
Use:
H1152 Dihydrochloride is mainly used as an experimental reagent in biochemical research. It can be used as a drug molecule to study cell activity, cell migration and tumor metastasis.
Preparation Method:
The preparation method of H1152 dihydrochloride can be completed by organic synthesis methods in the chemical synthesis laboratory. Specific steps include synthesizing a suitable intermediate, and then subjecting the intermediate to subsequent reaction and purification steps to obtain the target product.
Safety Information:
Under proper use and handling, H1152 Dihydrochloride is generally relatively safe. However, as with the use of other chemicals, strict adherence to laboratory safety practices is required. This includes wearing appropriate protective equipment, properly storing chemicals, and ensuring that they are used away from open flames and harmful gases. In addition, there is a need to follow relevant regulations and guidelines for the proper disposal of waste. If you come into contact with H1152 dihydrochloride, rinse immediately with plenty of water and seek medical help. In General, appropriate safety measures and laboratory practices can ensure the safe use of chemicals.
Nature:
H1152 dihydrochloride (chemical name:(R)-( )-2-Cyano-3-(3-(4-pyridyl)thieno[3,2-d]pyrimidin-6-yl)prop-2-enamide dihydrochloride) it is a white to yellowish Crystal, solid at room temperature. It is a selective Rho-kinase inhibitor that inhibits the transforming growth factor beta (TGF-β) signaling pathway.
Use:
H1152 Dihydrochloride is mainly used as an experimental reagent in biochemical research. It can be used as a drug molecule to study cell activity, cell migration and tumor metastasis.
Preparation Method:
The preparation method of H1152 dihydrochloride can be completed by organic synthesis methods in the chemical synthesis laboratory. Specific steps include synthesizing a suitable intermediate, and then subjecting the intermediate to subsequent reaction and purification steps to obtain the target product.
Safety Information:
Under proper use and handling, H1152 Dihydrochloride is generally relatively safe. However, as with the use of other chemicals, strict adherence to laboratory safety practices is required. This includes wearing appropriate protective equipment, properly storing chemicals, and ensuring that they are used away from open flames and harmful gases. In addition, there is a need to follow relevant regulations and guidelines for the proper disposal of waste. If you come into contact with H1152 dihydrochloride, rinse immediately with plenty of water and seek medical help. In General, appropriate safety measures and laboratory practices can ensure the safe use of chemicals.
Last Update：2024-04-09 20:52:54
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Product Name: H-1152 Dihydrochloride Visit Supplier Webpage Request for quotation
CAS: 871543-07-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 871543-07-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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